{"id":6671,"date":"2025-02-26T16:26:28","date_gmt":"2025-02-26T08:26:28","guid":{"rendered":"https:\/\/www.csclinic.com.tw\/?p=6671"},"modified":"2025-11-28T10:11:02","modified_gmt":"2025-11-28T02:11:02","slug":"%e5%8d%8a%e5%b9%b4%e4%b8%80%e9%87%9d%ef%bc%8c%e8%bc%95%e9%ac%86%e9%99%8d%e8%84%82%ef%bc%9a%e5%b0%8f%e5%88%86%e5%ad%90rna%ef%bc%88sirna%ef%bc%89%e6%8a%80%e8%a1%93%e9%87%8d%e5%a1%91%e8%a1%80%e8%84%82","status":"publish","type":"post","link":"https:\/\/www.csclinic.com.tw\/%e5%8d%8a%e5%b9%b4%e4%b8%80%e9%87%9d%ef%bc%8c%e8%bc%95%e9%ac%86%e9%99%8d%e8%84%82%ef%bc%9a%e5%b0%8f%e5%88%86%e5%ad%90rna%ef%bc%88sirna%ef%bc%89%e6%8a%80%e8%a1%93%e9%87%8d%e5%a1%91%e8%a1%80%e8%84%82\/","title":{"rendered":"\u534a\u5e74\u4e00\u91dd\uff0c\u8f15\u9b06\u964d\u8102\uff1a\u5c0f\u5206\u5b50RNA\uff08siRNA\uff09\u6280\u8853\u91cd\u5851\u8840\u8102\u7ba1\u7406\u65b0\u672a\u4f86\uff01"},"content":{"rendered":"

\u4e00\u3001\u5c0f\u5206\u5b50\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u6280\u8853\u5728\u8840\u8102\u7ba1\u7406\u4e2d\u7684\u61c9\u7528:<\/strong><\/h2>\n

\u5728\u53f0\u7063\uff0c\u9ad8\u8840\u8102\u7684\u500b\u6848\u4eba\u6578\u9010\u5e74\u589e\u52a0\uff0c\u800c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u904e\u9ad8\u66f4\u662f\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u91cd\u8981\u5371\u96aa\u56e0\u5b50\uff0c\u50b3\u7d71\u7684\u964d\u8102\u6cbb\u7642\u65b9\u5f0f\u5c0d\u90e8\u5206\u500b\u6848\u6548\u679c\u6709\u9650\uff0c\u6216\u56e0\u526f\u4f5c\u7528\u5c0e\u81f4\u6cbb\u7642\u4e2d\u65b7\u3002\u8fd1\u671f\uff0c\u5c0f\u5e72\u64feRNA\uff08siRNA\uff09\u6280\u8853\u7684\u61c9\u7528\u5e36\u4f86\u4e86\u5168\u65b0\u7684\u6cbb\u7642\u601d\u7dad\uff0c\u4ee5\u66f4\u6709\u6548
\n\u7684\u65b9\u5f0f\u5e6b\u52a9\u500b\u6848\u9577\u671f\u63a7\u5236LDL-C\u5e73\u8861\uff0c\u5c24\u5176\u9069\u5408\u96e3\u4ee5\u900f\u904e\u50b3\u7d71\u7642\u6cd5\u9054\u6a19\u7684\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u500b\u6848\uff0c\u9019\u9805\u6280\u8853\u6700\u65e9\u7531\u7f8e\u570b\u548c\u6b50\u6d32\u7684\u751f\u6280\u516c\u53f8\u9032\u884c\u7814\u767c\uff0c\u5c24\u5176\u4ee5\u5c08\u6ce8RNAi \u6280\u8853\u7684\u88fd\u85e5\u516c\u53f8\u5982Alnylam Pharmaceuticals \u70ba\u4ee3\u8868\uff0c\u4ed6\u5011\u7d50\u5408\u5148\u9032\u7684\u57fa\u56e0\u7de8\u8f2f\u8207\u5206\u5b50\u751f\u7269\u5b78\u6280\u8853\uff0c\u7814\u767c\u51fa\u80fd\u5920\u7cbe\u6e96\u6291\u5236PCSK9\u57fa\u56e0\u8868\u9054\u7684siRNA\u88fd\u5291\uff0c\u9019\u9805\u6280\u8853\u76ee\u524d\u5df2\u5728\u5168\u7403\u591a\u500b\u570b\u5bb6\u9032\u884c\u81e8\u5e8a\u8a66\u9a57\uff0c\u4e26\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u7ba1\u7406\u5c40\uff08FDA\uff09\u53ca\u6b50\u76df\u85e5\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u7684\u6838\u51c6\uff0c\u6210\u70ba\u964d\u8102\u6cbb\u7642\u7684\u65b0\u9078\u64c7\uff0c\u800c\u53f0\u7063\u91ab\u7642\u6a5f\u69cb\u4e5f\u5f15\u9032\u9019\u9805\u5275\u65b0\u7642\u6cd5\uff0c\u9010\u6b65\u5ee3\u6cdb\u61c9\u7528\u65bc\u9ad8\u98a8\u96aa\u5fc3\u8840\u7ba1\u75be\u75c5\u500b\u6848\u7684\u8840\u8102\u7ba1\u7406\u4e2d\u3002<\/p>\n

\"\"<\/h2>\n

 <\/p>\n

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\u4ee5siRNA\u6280\u8853\u70ba\u6838\u5fc3\uff0c\u9019\u7a2e\u6cbb\u7642\u5c08\u9580\u4f5c\u7528\u65bc\u809d\u81df\u5167\u90e8\uff0c\u9776\u5411\u6291\u5236\u8207PCSK9\u86cb\u767d\u751f\u6210\u76f8\u95dc\u7684mRNA\u3002PCSK9\u7684\u529f\u80fd\u5c31\u50cf\u662f\u4e00\u500b\u300c\u4e82\u69cd\u6253\u9ce5\u7684\u7375\u4eba\u300d\uff0c\u5b83\u6703\u96a8\u610f\u7834\u58de\u809d\u81df\u4e2d\u5c08\u9580\u8ca0\u8cac\u6e05\u9664\u58de\u81bd\u56fa\u9187\uff08LDL-C\uff09\u7684\u300c\u6355\u6349\u9677\u9631\u300d\uff08\u4e5f\u5c31\u662fLDL\u53d7\u9ad4\uff09\u3002\u9019\u4e9b\u300c\u9677\u9631\u300d\u7684\u4f5c\u7528\u662f\u6355\u7372\u8840\u6db2\u4e2d\u7684\u58de\u81bd\u56fa\u9187\uff0c\u5c07\u5176\u9001\u5230\u809d\u81df\u9032\u884c\u4ee3\u8b1d\u548c\u6e05\u7406\u3002\u7136\u800c\uff0c\u7576PCSK9\u6d3b\u6027\u904e\u9ad8\u6642\uff0c\u5b83\u5c31\u50cf\u5931\u63a7\u7684\u7375\u4eba\uff0c\u80e1\u4e82\u7834\u58de\u9019\u4e9b\u9677\u9631\uff0c\u5c0e\u81f4\u58de\u81bd\u56fa\u9187\u7121\u6cd5\u9806\u5229\u88ab\u300c\u6355\u7375\u56de\u6536\u300d\uff0c\u6700\u7d42\u5806\u7a4d\u5728\u8840\u6db2\u4e2d\uff0c\u589e\u52a0\u4e86\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98a8\u96aa\u3002siRNA \u6280\u8853\u7684\u4ecb\u5165\uff0c\u5c31\u50cf\u662f\u70ba\u9019\u500b\u300c\u4e82\u69cd\u6253\u9ce5\u7684\u7375\u4eba\u300d\u6c92\u6536\u4e86\u6b66\u5668\uff0c\u8b93\u5b83\u7121\u6cd5\u518d\u7834\u58de\u300c\u6355\u6349\u9677\u9631\u300d\u3002\u540c\u6642\uff0c\u9019\u9805\u6280\u8853\u9084\u53ef\u4ee5\u5e6b\u52a9\u91cd\u65b0\u4fee\u5fa9\u4e26\u4fdd\u8b77\u9019\u4e9b\u300c\u9677\u9631\u300d\uff0c\u78ba\u4fdd\u5b83\u5011\u80fd\u5920\u6b63\u5e38\u904b\u4f5c\u3002\u7576LDL\u53d7\u9ad4\u6578\u91cf\u589e\u52a0\u5f8c\uff0c\u809d\u81df\u5c31\u80fd\u66f4\u9ad8\u6548\u5730\u6355\u6349\u548c\u6e05\u7406\u8840\u6db2\u4e2d\u7684\u58de\u81bd\u56fa\u9187\uff0c\u5be6\u73fe\u5feb\u901f\u800c\u7a69\u5b9a\u7684\u964d\u8102\u6548\u679c\u3002<\/p>\n

<\/h2>\n

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 <\/p>\n

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\"\"<\/h2>\n

 <\/p>\n

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\n\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98a8\u96aa\u6975\u9ad8\u7684\u500b\u6848\uff0c\u4f8b\u5982\u5df2\u6709\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\uff08ASCVD\uff09\u6216\u591a\u91cd\u5371\u96aa\u56e0\u7d20\u7684\u500b\u6848\uff0c\u9700\u5c07LDL-C\u964d\u81f3\u66f4\u4f4e\u6c34\u5e73\u4ee5\u9810\u9632\u4e8b\u4ef6\u5fa9\u767c\u3002
\n2. \u5bb6\u65cf\u6027\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u500b\u6848<\/strong><\/span>
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\n3. \u5c0d\u4ed6\u6c40\u985e\u85e5\u7269\u4e0d\u8010\u53d7\u8005<\/strong><\/span>
\n\u90e8\u5206\u500b\u6848\u56e0\u808c\u8089\u75bc\u75db\u6216\u809d\u9176\u5347\u9ad8\u7b49\u526f\u4f5c\u7528\uff0c\u7121\u6cd5\u63a5\u53d7\u4ed6\u6c40\u985e\u6cbb\u7642\uff0c\u8a72\u88fd\u5291\u63d0\u4f9b\u4e86\u4e00\u7a2e\u66ff\u4ee3\u65b9\u6848\uff0c\u80fd\u7368\u7acb\u6216\u8207\u4f4e\u5291\u91cf\u4ed6\u6c40\u806f\u7528\u3002
\n4. \u4ed6\u6c40\u6cbb\u7642\u6548\u679c\u4e0d\u4f73\u7684\u500b\u6848<\/strong><\/span>
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\"\"<\/p>\n

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\n2. \u56b4\u91cd\u809d\u529f\u80fd\u640d\u5bb3\u7684\u500b\u6848\u9700\u8b39\u614e\u4f7f\u7528\uff0c\u56e0\u8a72\u88fd\u5291\u4e3b\u8981\u5728\u809d\u81df\u767c\u63ee\u4f5c\u7528\uff0c\u809d\u529f\u80fd\u4e0d\u5168\u53ef\u80fd\u5f71\u97ff\u7642\u6548\u6216\u589e\u52a0\u4e0d\u826f\u53cd\u61c9\u98a8\u96aa\u3002
\n3. \u61f7\u5b55\u6216\u54fa\u4e73\u671f\u5a66\u5973\uff1a\u76ee\u524d\u5c1a\u7121\u5145\u5206\u6578\u64da\u652f\u6301\u6b64\u985e\u4eba\u7fa4\u4f7f\u7528\u8a72\u88fd\u5291\uff0c\u5efa\u8b70\u6cbb\u7642\u671f\u9593\u907f\u514d\u61f7\u5b55\u3002
\n4. \u4f4e\u81bd\u56fa\u9187\u75c7\u500b\u6848\uff08\u5982\u7f55\u898b\u7684\u5bb6\u65cf\u6027\u4f4e\u81bd\u56fa\u9187\u8840\u75c7\uff09\u9700\u8b39\u614e\u4f7f\u7528\uff0c\u907f\u514d\u81bd\u56fa\u9187\u904e\u5ea6\u4e0b\u964d\u5c0d\u7d30\u80de\u819c\u53ca\u6fc0\u7d20\u5408\u6210\u7684\u5f71\u97ff\u3002<\/p>\n

 <\/p>\n

\"\"<\/h2>\n

 <\/p>\n

\u516d\u3001\u5728\u53f0\u7063\u5e02\u5834\u7684\u61c9\u7528\u73fe\u72c0\u8207\u672a\u4f86\u524d\u666f<\/strong><\/h2>\n

\u9019\u6a23\u7684\u65b0\u7642\u6cd5\u5728\u53f0\u7063\u591a\u7528\u65bc\u9810\u9632\u8207\u9700\u7a4d\u6975\u964d\u8102\u7684\u9ad8\u98a8\u96aa\u500b\u6848\uff0c\u7531\u65bc\u5176\u6cbb\u7642\u65b9\u6848\u7c21\u4fbf\u4e14\u6548\u679c\u6301\u4e45\uff0c\u6df1\u53d7\u91ab\u5e2b\u8207\u500b\u6848\u7684\u9752\u775e\u3002\u7136\u800c\u7531\u65bc\u50f9\u683c\u8f03\u9ad8\uff0c\u76ee\u524d\u4e3b\u8981\u9069\u7528\u65bc\u5065\u4fdd\u7121\u6cd5\u6db5\u84cb\u7684\u81ea\u8cbb\u5e02\u5834\uff0c\u5c24\u5176\u662f\u5bb6\u5ead\u9810\u9632\u91ab\u5b78\u3001\u5fc3\u8840\u7ba1\u79d1\u5225\u53ca\u5167\u5206\u6ccc\u79d1\u7b49\u5c08\u79d1\u9580\u8a3a\u4e2d\u3002\u96a8\u8457\u5168\u7403\u5fc3\u8840\u7ba1\u75be\u75c5\u9632\u6cbb\u6307\u5357\u5c0dLDL-C\u76ee\u6a19\u503c\u7684\u4e0d\u65b7\u964d\u4f4e\uff0c\u6b64\u88fd\u5291\u5728\u9810\u9632\u6027\u91ab\u7642\u4e2d\u7684\u5730\u4f4d\u5c07\u66f4\u52a0\u91cd\u8981\uff0c\u672a\u4f86\u53ef\u80fd\u6210\u70ba\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u7684\u4e00\u90e8\u5206\u3002
\n\u57fa\u65bc\u9019\u9805\u65b0\u6280\u8853\u7684\u65b0\u578b\u964d\u8102\u88fd\u5291\u70ba\u8840\u8102\u7ba1\u7406\u63d0\u4f9b\u4e86\u5275\u65b0\u4e14\u9ad8\u6548\u7684\u9078\u64c7\uff0c\u9069\u5408\u4e0d\u540c\u985e\u578b\u7684\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u500b\u6848\uff0c\u5728\u9078\u64c7\u6cbb\u7642\u65b9\u6848\u6642\uff0c\u5efa\u8b70\u500b\u6848\u8aee\u8a62\u5c08\u696d\u91ab\u5e2b\u8a55\u4f30\u9069\u7528\u6027\uff0c\u4e26\u6839\u64da\u81ea\u8eab\u5065\u5eb7\u72c0\u6cc1\u5236\u5b9a\u6700\u4f73\u6cbb\u7642\u8a08\u5283\uff0c\u6280\u8853\u4e0d\u50c5\u662f\u4e00\u5834\u91ab\u7642\u9769\u65b0\uff0c\u66f4\u53ef\u80fd\u6210\u70ba\u5fc3\u8840\u7ba1\u75be\u75c5\u7ba1\u7406\u7684\u65b0\u6a19\u6e96\u3002<\/p>\n

 <\/p>\n

\u4e03\u3001\u6587\u737b\u53c3\u8003<\/strong><\/h2>\n

\u570b\u5167\u6587\u737b\uff1a
\n1. \u674e\u8cbd\u6052\u3001\u77f3\u5d07\u826f\u7b49. (2024). \u53f0\u7063\u8840\u8102\u7ba1\u7406\u81e8\u5e8a\u8def\u5f91\u5171\u8b58. \u53f0\u7063\u5167\u79d1\u91ab\u5b78\u6703\u671f\u520a, 33(4), 245-256. \u53d6\u81ea https:\/\/www.tsim.org.tw
\n2. \u8449\u570b\u6384. (2024). \u5404\u6709\u6240\u9577\u7684siRNA\u8207miRNA. The Investigator Taiwan, 20(3), 101-115. \u53d6\u81ea https:\/\/investigator.tw
\n3. \u6797\u6c81\u8431\u3001\u838a\u5cfb\u6bc5\u3001\u5433\u6c42\u73cd. (2021). \u964d\u8840\u8102\u65b0\u85e5PCSK9\u751f\u5408\u6210\u6291\u5236\u5291Inclisiran. \u85e5\u5b78\u96dc\u8a8c\u96fb\u5b50\u5831, 155, 66-70. \u53d6\u81ea
\nhttps:\/\/jtp.taiwan-pharma.org.tw\/155\/066-070.html<\/p>\n

\u570b\u5916\u6587\u737b\uff1a
\n1. Ray, K. K., Landmesser, U., Leiter, L. A., Kallend, D., Dufour, R., Karakas, M., Hall, T., Troquay, R. P. T., Turner, T., & Dangas, G. D. (2017). Inclisiran in patients at high cardiovascular risk with elevated LDL cholesterol. New England Journal of Medicine, 376(15), 1430-1440. https:\/\/doi.org\/10.1056\/NEJMoa1615758
\n2. Ray, K. K., Wright, R. S., Kallend, D., Koenig, W., Leiter, L. A., Raal, F. J., Kastelein, J. J. P., Landmesser, U., Wijngaard, P. L. J., & Kastelein, J. J. P. (2020). Safety and efficacy of inclisiran in patients with elevated LDL cholesterol. New England Journal of Medicine, 382(16), 1507 1519. https:\/\/doi.org\/10.1056\/NEJMoa1912387
\n3. Raal, F. J., Kallend, D., Ray, K. K., Turner, T., Koenig, W., Wright, R. S., Kastelein, J. J. P., Landmesser, U., Wijngaard, P. L. J., & Dufour, R. (2020). Inclisiran for the treatment of heterozygous familial hypercholesterolemia. New England Journal of Medicine, 382(16), 1520-1530. https:\/\/doi.org\/10.1056\/NEJMoa1913805<\/p>\n

 <\/p>\n

\"\"<\/p>\n

 <\/p>\n

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